Tier 1

Pump Shotgun

Does 25 damage per pellet and 250 damage if all pellets hit. (10 pellets)
Does 2000 damage per clip if all pellets hit, should take 3 magazines to kill a Tank when up-close.
Requires a pump after each shot.
The Chrome Pump Shotgun is the most basic shotgun in the game. It deals high damage at close range but the spread causes it to be ineffective at medium to long range. It was revealed in very early builds of the Left 4 Dead 2 beta and rarely seen. It is modeled after the Remington 870 Marine Magnum.

Sub-machine Gun

Does 20 damage per shot.
Does 950 damage per magazine, so it takes 7 magazines to kill a Tank.
More accurate than the Silenced Submachine Gun.
The Sub-machine Gun deals light progressive damage. It holds 50 rounds with 480 in reserve, and has enough accuracy to shoot at medium range. Although it is replaced by the assault rifle in tier 2, it still has the highest rate of fire. It also has noticeable stopping power. The main drawback to the sub-machine gun is the high rate of ammo expenditure; most Survivors using a sub-machine gun will run out of ammo partially through a level if they aren’t conservative with their shooting. However, it is great for medium-ranged closed-quarters such as large warehouses and apartments. Its high rate of fire, penetration and accuracy make it a longer ranged alternative to the pump shotgun.

Silenced Sub-machine Gun

Does 25 damage per shot. CI has 50hp on Normal/Advanced and 90 on Expert.
Does 1250 damage per magazine, so it should take 5 magazines to kill a Tank if you aim good.
The Silenced Sub-machine Gun fires its rounds at a very high rate of fire. All the rounds in one magazine can be fired in 5 seconds. It has a capacity of 50 rounds per magazine. It is modeled after the Military Armament Corporation M10 sub-machine gun (colloquially known as the MAC-10) with a suppressor.

3-burst Shotgun [?]

SIG SG 552

Chrome Shotgun

Does 24 damage per pellet and 240 damage if all pellets hit. (10 pellets)
Does 1920 damage per clip, should take 4 magazines to kill a Tank.
More accurate than the Pump Shotgun.
Requires a pump after each shot.

The Chrome Pump Shotgun is the most basic shotgun in the game. It deals high damage at close range but the spread causes it to be ineffective at medium to long range. It was revealed in very early builds of the Left 4 Dead 2 beta and rarely seen. It is modeled after the Remington 870 Marine Magnum.

Tier 2

Auto Shotgun (Tactical)

28 damage per pellet, 280 if all pellets hits.
2880 damage per magazine, should kill a Tank in 3 magazines.
The auto shotgun is the next weapon up from the pump shotgun. It doesn’t require a pump after every shot so it can be fired much faster, but if reloaded from empty magazine, the bolt must be pulled, which takes a second,so its best to reload before the weapon is empty. The rate of fire is an advantage for wiping out crowds of Infected and cr0wning Witches. On a side note it’s effectiveness against Tanks has been decreased. The range and power of the shots is also improved. It is modeled after the Benelli M1014 semi-automatic shotgun.

Hunting Rifle

Does 90 damage per shot, and 1-shots CIs on any difficulty unless you aim for the limbs.
Does 1350 damage per magazine, should take 5 magazines to kill a Tank.
The hunting rifle has an attached scope that can be used to pick off Infected from long distances away. However, it is extremely ineffective at close range as each shot must be aimed at individual Infected. It’s the best weapon to use if Infected pack into small tunnels or hallways because of the power and ability to blow through Infected and hit others. It may also be used to penetrate walls. This is an effective weapon to kill Smokers who are on top of buildings or hills. It is modeled after the Ruger Mini-14 rifle.

Assault Rifle

Does 33 damage per shot.
Does 1650 damage per magazine, should take 4 magazines to kill a Tank.
The assault rifle is a fully automatic weapon that deals high damage at long range. It is more effective than the submachine gun in all respects, doing more damage with higher accuracy. This is effective at killing special infected at a distance and dealing constant damage at a closer range. It can be effectively used on Tanks if attacking at a close range. It is modeled after the M16A2 assault rifle. It is confirmed that it is the M16A2 because it says it right on the gun in the game.

Sniper Rifle

90 damage per shot, 1-shots all CIs.
2700 damage per magazine, should take 3 magazines to kill a Tank.
Holds more ammo per magazine.
The Sniper Rifle will do more damage against Special Infected while still killing the Common Infected in one hit. It will also be more accurate when moving and be black in color instead of the wood brown of its predecessor. It has a capacity of 30 rounds each magazine; increased from the 15 from before. It is suspected that this will be a Tier 2 weapon. It is modeled after the Heckler & Koch G3SG/1 rifle, a scoped G3 variant

Spas-12 (Combat Shotgun)

Does 44 damage per shot. (Not sure if this means per burst or per bullet)
Does 2640 damage per magazine, 3 magazines to kill a Tank.

The Combat Shotgun fires shotgun shells and has a capacity of 10 shells each reload. It is modeled after the Franchi SPAS-12 Semi-Automatic Shotgun.

SCAR (Combat Rifle)

The Combat Rifle is an automatic weapon that has a capacity of 60 rounds per magazine and fires in three-round bursts. It is suspected that this will be a Tier 2 weapon. It is modeled after the Fabrique Nationale SCAR-L assault rifle.

Special Tier

Grenade Launcher

Does same damage as a Pipe-bomb.
Can not gain more ammo from ammo piles.
Kill radius varies on difficulty.
The Grenade Launcher is a weapon in Left 4 Dead 2. Based on footage from Comic Con, it appears to be a M79 Grenade Launcher. Not much is known about the grenade launcher other than “it liquefies flesh-eaters with remarkable efficiency.” It fires one shell at a time and takes around two or three seconds to reload. It takes the place of the primary weapon. It appears to have the same power as the pipe bomb. It also has the worst friendly fire damage,

AK-47

Does 58 damage per shot.
Does 2320 damage per magazine, should take 3 magazines to kill a Tank.

The AK-47 is an Assault Rifle in Left 4 Dead 2. It can be found mostly in the location of the SCAR in areas where the assault rifle spawns.

Mini-gun
Heavy Machine Gun

Grenades

Molotov Cocktail

Pipe bomb
Boomer Bile Bomb

Explosives

Oxygen Tank

Gas Can

Propane Tank

Fireworks

Sidearm

P220 Pistol (Can be dual-wielded)

Does 525 damage per magazine, 1050 when dual wielded. Takes 12 magazines to kill a Tank, and 6 magazines when dual wielded.
Infinite ammo.
The SIG Sauer P220 Pistol is the backup weapon of the Survivors in Left 4 Dead 2. It is one of the weapons they can use when knocked down, although with a slower rate of fire and greatly decreased accuracy. The pistol(s) is one of the only weapons that has infinite ammunition. However, they are still limited to a magazine capacity of 15 rounds.